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Use of Carbonic Anhydrase Inhibitors in Prevention & Treatment of Acute Mountain Sickness:

Scientists mostly agree that acute mountain sickness (AMS) is caused by hypoxia at high altitude and a failure to adapt to that hypoxia (hence occurring more rapidly at rapid ascent cause of less time for adaptation). Hypoxia leads to hyperventilation... Continue Reading →

Advantages of LMW Heparins over UFH

Low Molecular Weight Heparins (LMWH) like enoxaparin have the following advantages over unfractionated heparin (UFH): 1. Predictable pharmacokinetics and predictable plasma levels mainly because they don’t bind to plasma proteins, macrophages or endothelial cells 2. Thus no need of monitoring... Continue Reading →

Advantages of ORAL DTIs (Direct Thrombin Inhibitors) over warfarin

The direct thrombin inhibitors (DTIs) exert their anticoagulant effect by directly binding to the active site of thrombin, thereby inhibiting thrombin's downstream effects. This is in contrast to indirect thrombin inhibitors such as heparin and LMWH (see above), which act... Continue Reading →

Pharmacology MCQs-Chemotherapy

1. Which one are a group of Anti-metabolites? a)      Aminoglycosides b)     Carbapenems c)      Fluoroquinolones d)     Polyenes e)      Sulfonamides 2. Which one of the following agents are narrow spectrum antibiotics? a)      Aminoglycosides b)     Cotrimoxazole c)      Fluoroquinolones d)     Tetracyclines 3. Which one... Continue Reading →

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